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M1387

Sigma-Aldrich

4-Methylpyrazole hydrochloride

alcohol dehydrogenase inhibitor

Synonym(s):

Fomepizole

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1 PKG
CA$2,490.00

About This Item

Empirical Formula (Hill Notation):
C4H6N2 · HCl
CAS Number:
Molecular Weight:
118.56
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

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biological source

synthetic (organic)

Quality Level

assay

≥95%

form

powder

mp

157-159  °C

solubility

methanol: 100 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.Cc1cn[nH]c1

InChI

1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H

InChI key

PUCXJHNDMYZOHG-UHFFFAOYSA-N

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This Item
C13408B6506M6500
assay

≥95%

assay

98%

assay

≥99%

assay

≥98% (titration)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

Gene Information

human ... ADH1A(124), ADH1B(125), ADH1C(126)

Gene Information

-

Gene Information

-

Gene Information

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

crystalline powder, powder or crystals

form

powder

form

powder or crystals

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

4-Methylpyrazole hydrochloride has been used:
  • as a cytochrome P450 2E1 inhibitor[1]
  • as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells[2]
  • to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells[3]

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes.[4] It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.[5]
Alcohol dehydrogenase inhibitor

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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