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M168

Sigma-Aldrich

Methyllycaconitine citrate salt

from Delphinium brownii seeds, ≥96% (HPLC)

Synonym(s):

MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt

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CA$16,010.00

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1 EA
CA$16,010.00

About This Item

Empirical Formula (Hill Notation):
C37H50N2O10 · xC6H8O7
CAS Number:
Molecular Weight:
682.80 (salt-free basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

CA$16,010.00


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biological source

Delphinium brownii seeds

Quality Level

assay

≥96% (HPLC)

color

white

solubility

H2O: 42 mg/mL

storage temp.

−20°C

SMILES string

O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O

InChI

1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1

InChI key

INBLZNJHDLEWPS-DDIMIZGISA-N

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1 of 4

This Item
EP6313000018EP6316000019EP6315000015
parameter

1-30 °C (gradient range), 37-110 °C temp. range, 30-99 °C (gradient temperature), 4-99 °C temp. range (control range)

parameter

1-30 °C (gradient range), 30-99 °C (gradient temperature), 37-110 °C temp. range, 4-99 °C temp. range (control range)

parameter

1-30 °C (gradient range), 30-99 °C (gradient temperature), 37-110 °C temp. range, 4-99 °C temp. range (control range)

parameter

1-30 °C (gradient range), 30-99 °C (gradient temperature), 37-110 °C temp. range, 4-99 °C temp. range (control range)

W × D × H

27.5 cm × 43 cm × 33 cm

W × D × H

27.5 cm × 43 cm × 33 cm

W × D × H

27.5 cm × 43 cm × 33 cm

W × D × H

27.5 cm × 43 cm × 33 cm

feature

Unit can control 9 other units in network, unit can only be controlled, holds 1 PCR plate 8×12, with control panel

feature

Unit can control 9 other units in network, holds 96×0.2 mL PCR vessels, 1 PCR plate 8 × 12, unit can only be controlled, with control panel

feature

Unit can control 9 other units in network, high pressure lid, holds 1 PCR plate 8×12, unit can only be controlled, with control panel

feature

Unit can control 9 other units in network, high pressure lid, holds 1 PCR plate 8×12, unit can only be controlled, with control panel

material

silver block

material

aluminum block

material

aluminum block

material

aluminum block

manufacturer/tradename

Eppendorf® 6311000010

manufacturer/tradename

Eppendorf® 6313000018

manufacturer/tradename

Eppendorf® 6316000019

manufacturer/tradename

Eppendorf® 6315000015

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

Application

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
  • to study its effects on inflammatory response in rats post nicotine treatment[1]
  • to block the activity of galantamine[2]
  • to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats[3]

Biochem/physiol Actions

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium.[4] MLA binds to the binding site of neuronal α-bungarotoxin.[5] Low doses of MLA are associated with improvement of cognition in animals.[4]

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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