M5060

E-4031

≥98% (HPLC), lyophilized powder

• Synonym(s): N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
• Empirical Formula (Hill Notation): C₂₁H₂₇N₃O₃S · 2HCl
• CAS Number: 113559-13-0
• Molecular Weight: 474.44
• MDL number: MFCD01754739
• UNSPSC Code: 12352207
• PubChem Substance ID: 329818000
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: lyophilized powder
• storage condition: desiccated
• technique(s): cell culture | embryo: suitable
• color: white
• solubility: H₂O: soluble
• storage temp.: −20°C
• SMILES string: Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
• InChI: 1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
• InChI key: ZQBNWMFBOSOOLX-UHFFFAOYSA-N

Description

Application

E-4031 has been used as:

• human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)[1]
• IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies[2]
• IKr blocker in rat ventricular myocytes[3]

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation.[4] E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits.[5] An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.[6]

E-4031 selectively blocks hERG K⁺ channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)