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M5435

Sigma-Aldrich

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

Synonym(s):

MPEP hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H11N · HCl
CAS Number:
219911-35-0
Molecular Weight:
229.70
MDL number:
MFCD02262119
UNSPSC Code:
12352200
PubChem Substance ID:
24278557
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

off-white to light tan

solubility

DMSO: 10 mg/mL, clear

storage temp.

room temp

SMILES string

Cl.Cc1cccc(n1)C#Cc2ccccc2

InChI

1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H

InChI key

PKDHDJBNEKXCBI-UHFFFAOYSA-N

Gene Information

human ... GRIN2B(2904), GRM5(2915)
rat ... Grm5(24418)

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This Item
147901014790311479053
USP

1479064

Orphenadrine Related Compound F

USP

1479010

Orphenadrine Related Compound A

USP

1479031

Orphenadrine Related Compound C

USP

1479053

Orphenadrine Related Compound E

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

USP

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

API family

orphenadrine

API family

orphenadrine

API family

orphenadrine

API family

orphenadrine

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

General description

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family.[1] It is located on chromosome 12p13.1.[2]

Application

6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).[3]

Biochem/physiol Actions

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory.[1] GRIN2B mutation is associated with neuropsychiatric and developmental disorders[1] like schizophrenia, Parkinson′s disease and bipolar disorder.[2] MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).[4]
Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    073M4704V
    BGBC0044
    061M4623V
    060M46052
    060M46051

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    The risk of infection in burns is well-known. In recent decades, the antimicrobial resistance of bacteria isolated from burn patients has increased. For this reason, a retrospective study was conducted at Van Training and Research Hospital to analyze the bacterial
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