N6287

Nutlin-3

≥98% (HPLC), powder, Mdm2 antagonist

• Synonym(s): (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
• Empirical Formula (Hill Notation): C₃₀H₃₀Cl₂N₄O₄
• CAS Number: 548472-68-0
• Molecular Weight: 581.49
• MDL number: MFCD07784509
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724554
• NACRES: NA.77

Properties

• Product Name: Nutlin-3, ≥98% (HPLC), powder
• ligand: nutlin-3
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• reaction suitability: reagent type: ligand
• solubility: DMSO: 20 mg/mL; H₂O: insoluble
• originator: Roche
• shipped in: wet ice
• storage temp.: −20°C

Description

Application

Nutlin-3 has been used:

• as a drug to stimulate p53 functions in gene transfer experiment[1]
• to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae[2]
• as a p53 activator in cyclotherapy studies[3]
• as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage[4]

Biochem/physiol Actions

Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer.

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53.[5] Nutlin-3 can also enhance the transcriptional activities of p73.[6]

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers.

Analysis Note

relative stereochemistry

Legal Information

Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves