N6287

Nutlin-3

≥98% (HPLC), powder, Mdm2 antagonist

• Synonyme(s) : (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
• Formule empirique (notation de Hill) : C₃₀H₃₀Cl₂N₄O₄
• CAS Number: 548472-68-0
• Poids moléculaire : 581.49
• Numéro MDL: MFCD07784509
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724554
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Nutlin-3, ≥98% (HPLC), powder
• ligand: nutlin-3
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Pertinence de la réaction: reagent type: ligand
• Solubilité: DMSO: 20 mg/mL; H₂O: insoluble
• Auteur: Roche
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: O=C(N1CC(NCC1)=O)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=C(OC(C)C)C=C(OC)C=C5
• InChI: 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
• Clé InChI: BDUHCSBCVGXTJM-IZLXSDGUSA-N

Description

Application

Nutlin-3 has been used:

• as a drug to stimulate p53 functions in gene transfer experiment
• to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae
• as a p53 activator in cyclotherapy studies
• as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage

Actions biochimiques/physiologiques

Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer.

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers.

Remarque sur l'analyse

relative stereochemistry

Informations légales

Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves