N8773
Anti-Nerve Growth Factor-β antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-NGF-β
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Pricing and availability is not currently available.
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL
neutralization: 0.02-0.1 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
1 of 4
This Item | 16-228 | MABT524 | CBL458 |
|---|---|---|---|
| clone 4F11, monoclonal | clone 4F11, monoclonal | clone 5G3.2, monoclonal | clone 4F10, monoclonal |
| form liquid | form - | form - | form - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| isotype IgG1κ | isotype IgG1 | isotype IgG2bκ | isotype IgG2b |
| target post-translational modification unmodified | target post-translational modification - | target post-translational modification unmodified | target post-translational modification unmodified |
General description
Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions . Anti-Nerve Growth Factor-β antibody recognizes rat NGF-β. The antibody shows less than 1% cross reactivity with recombinant human β-NGF.
in the presence of 10.0μg/ml of recombinat rat β-NGF using the human erythroleukemic TF-1 cell line.
Immunogen
recombinant rat β-nerve growth factor expressed in Sf 21 cells.
Application
Anti-NGF-β antibody may be used for neutralization assays; the ND50 is ~0.02-0.1 μg/ml. For immunoblotting the recommended antibody concentration is 0.1-0.2 μg/ml. The antibody is suitable for immunohistochemistry at a working concentration of 5-15 μg/ml. For ELISA, antibody concentration of 0.2-0.8 μg/ml may be used. Antibody dilution of 1:500 was used for immunoblotting of extracts of rat nerve cells.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Margherita Maranesi et al.
Biology of reproduction, 98(5), 634-643 (2018-02-14)
To investigate the ovulatory mechanisms triggered by raw semen (RS) in rabbits, we examined the expression of nerve growth factor (NGF)-a supposed ovulation-inducing factor (OIF)-and cognate receptors in anterior pituitary, ovary, and cervix as well as plasma NGF and luteinizing
Bopaiah P Cheppudira et al.
BMC anesthesiology, 16(1), 73-73 (2016-09-07)
Nerve growth factor (NGF) is known to induce inflammation and pain; however its role in opioid-induced tolerance has not been studied. This study investigated the effects of an anti-NGF neutralizing antibody on the development of tolerance following chronic morphine treatment
Uros Kovacic et al.
Neurobiology of aging, 31(2), 339-350 (2008-05-24)
Sprouting of uninjured nociceptive axons was examined in young adult, middle aged and aged rats. Axon sprouting from the spared sural nerve, both into adjacent denervated skin and into end-to-side coapted nerve graft, was significantly higher in young rats than
Ana Sanchez-Rodriguez et al.
Theriogenology, 126, 206-213 (2018-12-24)
β-Nerve Growth Factor (β-NGF) is a neurotrophin which acts through its receptors TrkA and p75, performing important actions in male reproductive physiology and its presence in seminal plasma (SP) has been related to male fertility. The aim of the present
Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis
Indo Y
Clinical Genetics, 82, 341-350 (2010)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
