P0069

PRIMA-1

≥98% (HPLC), solid

• Synonym(s): 2,2-Bishydroxymethyl-1-aza-bicyclo[2.2.2]octan-3-one
• Empirical Formula (Hill Notation): C₉H₁₅NO₃
• CAS Number: 5608-24-2
• Molecular Weight: 185.22
• MDL number: MFCD04974196
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820004
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: OCC1(CO)N2CC[C@@H](CC2)C1=O
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI key: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Description

General description

P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy.[1][2] PRIMA-1 stimulates cytotoxic effects in human cancer cells.[2] It induces eryptosis.[3]

Biochem/physiol Actions

PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53.

PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H334
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves