P2363

Protein Kinase G II from rat

>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, solution

• Synonym(s): Protein Kinase, 3′,5′-Cyclic GMP Dependent from rat
• MDL number: MFCD03444648
• UNSPSC Code: 41106305
• NACRES: NA.32

Properties

• recombinant: expressed in baculovirus infected Sf9 cells
• Quality Level: 200
• assay: >90% (SDS-PAGE)
• form: solution
• specific activity: ~0.7 U/mg
• UniProt accession no.: Q64595
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: rat ... Prkg2(25523)

Description

General description

Protein kinase, cGMP-dependent, type II (PRKG2), also known as type II cGMP-dependent protein kinase (cGK), is encoded by the gene mapped to human chromosome 4q13.1–q21.1.

Biochem/physiol Actions

Protein kinase, cGMP-dependent, type II (PRKG2) is implicated in the regulation of intestinal fluid balance in man. The encoded protein plays an essential role in proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function is associated with the development of renal cysts, intellectual disability and speech defect. In rodent and bovine models, deletion of the gene leads to dwarfism.

Unit Definition

One unit will phosphorylate one μmole of VASPtide (RRKVSKQE) per minute at pH 7.4

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable