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P5248

Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Synonym(s):

Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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About This Item

Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
CAS Number:
7414-83-7
Molecular Weight:
249.99 (anhydrous basis)
EC Number:
231-025-7
MDL number:
MFCD00152567
UNSPSC Code:
12352200
PubChem Substance ID:
329820220
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥97% (NMR)

form

solid

color

white

mp

>300 °C

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

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Etidronate disodium hydrate ≥97% (NMR), solid

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Ibandronate sodium salt ≥97% (NMR), solid

I5784

Ibandronate sodium salt

form

solid

form

solid

form

solid

form

solid

assay

≥97% (NMR)

assay

≥95% (NMR)

assay

≥98% (HPLC)

assay

≥97% (NMR)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: ≥10 mg/mL

solubility

H2O: 28 mg/mL

solubility

DMSO: >10 mg/mL

solubility

H2O: >10 mg/mL

color

white

color

white

color

white to beige

color

white

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase.[1] It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).[2]

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.[3]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    043M4617V
    030M46201
    030M4620
    075K4613
    015K4619

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    Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase
    Sillero M A G, et al.
    Febs Letters, 580(24), 5723-5727 (2006)
    Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
    Griffin S, et al.
    Biology of Reproduction (2018)
    Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway
    Su J and Huang M
    European Journal of Pharmacology, 841, 75-81 (2018)
    Richard Choo et al.
    International journal of radiation oncology, biology, physics, 85(5), 1239-1245 (2012-12-26)
    Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this
    Ping Yin et al.
    Journal of agricultural and food chemistry, 60(47), 11664-11674 (2012-11-01)
    Novel biosorbent materials obtained from agricultural residues buckwheat hulls (BH) were successfully developed through functionalization with 1-hydroxylethylidenediphosphonic acid (HEDP), and they were characterized. This paper reports the feasibility of using HEDP-BH for removal of heavy metals from stimulated wastewater, the
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