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P5248

Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Synonym(s):

Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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About This Item

Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
CAS Number:
7414-83-7
Molecular Weight:
249.99 (anhydrous basis)
EC Number:
231-025-7
MDL number:
MFCD00152567
UNSPSC Code:
12352200
PubChem Substance ID:
329820220
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥97% (NMR)

form

solid

color

white

mp

>300 °C

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

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Etidronate disodium hydrate ≥97% (NMR), solid

P5248

Etidronate disodium hydrate

Pamidronate disodium salt hydrate ≥95% (NMR), solid

P2371

Pamidronate disodium salt hydrate

(E/Z)-Endoxifen Hydrochloride Hydrate ≥98% (HPLC)

E8284

(E/Z)-Endoxifen Hydrochloride Hydrate

Ibandronate sodium salt ≥97% (NMR), solid

I5784

Ibandronate sodium salt

assay

≥97% (NMR)

assay

≥95% (NMR)

assay

≥98% (HPLC)

assay

≥97% (NMR)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: ≥10 mg/mL

solubility

H2O: 28 mg/mL

solubility

DMSO: >10 mg/mL

solubility

H2O: >10 mg/mL

color

white

color

white

color

white to beige

color

white

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase.[1] It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).[2]

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.[3]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    043M4617V
    030M46201
    030M4620
    075K4613
    015K4619

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