P5556

Poloxamer 188 solution

10%, sterile-filtered, BioReagent, suitable for insect cell culture

• Synonym(s): Nonionic copolymer surfactant
• CAS Number: 9003-11-6
• MDL number: MFCD00082049
• UNSPSC Code: 12161902
• PubChem Substance ID: 24898666
• NACRES: NA.75

Properties

• description: non-ionic
• Quality Level: 400
• sterility: sterile-filtered
• product line: BioReagent
• mol wt: average mol wt 8350
• concentration: 10%
• technique(s): cell culture | insect: suitable
• impurities: endotoxin, tested
• transition temp: cloud point ≥100
• HLB: 29
• SMILES string: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.

Application

A nonionic copolymer surfactant

Biochem/physiol Actions

Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)