PLA0126

Rabbit anti-Phospho 53BP1 (S25) Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): 1, 53BP1, TDRD30, TP53, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, tumor protein p53-binding protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: mouse, human
• technique(s): immunohistochemistry: 1:1,000- 1:5,000; immunoprecipitation (IP): 1- 4 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_005648.1
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: phosphorylation (pSer25 )

Description

Immunogen

Immunogen for PLA0126 was a phosphorylated synthetic peptide, which represented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25 according to the numbering given in entry NP_005648.1.

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable