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Key Documents

PLA0243

Sigma-Aldrich

Rabbit anti-FANCD2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia, Protein FACD2, complementation group D2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 5-15 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_001018125.1

UniProt accession no.

Q9BXW9

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... FANCD2(2177)

Immunogen

The epitope recognized by PLA0243 maps to a region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 using the numbering given in entry NP_001018125.1 (GeneID 2177).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Spencer W Luebben et al.
Nucleic acids research, 42(9), 5605-5615 (2014-03-05)
Accumulating evidence suggests that dormant DNA replication origins play an important role in the recovery of stalled forks. However, their functional interactions with other fork recovery mechanisms have not been tested. We previously reported intrinsic activation of the Fanconi anemia
Guang-Hui Liu et al.
Nature communications, 5, 4330-4330 (2014-07-08)
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we

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