PRS4237

Anti-Op18 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-LAP18, Anti-Lag, Anti-Oncoprotein 18, Anti-STMN1, Anti-Stathmin 1
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, mouse, rat
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: P16949
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... STMN1(3925)

Description

General description

Op18 (oncoprotein 18) is a cytoplasmic phosphoprotein, that is of 17kDa. It is also termed as stathmin1 (STMN1). It is partially found in the nucleus of all tumor tissues. It is located on chromosome 1p36.1.

Immunogen

a 17 amino acid peptide from near the amino-terminus of human op18.

Biochem/physiol Actions

Op18 (oncoprotein 18) plays a major role in the multiplication and migration of hypopharyngeal squamous cell carcinoma (HSCC), hence it can be considered as a therapeutic target of HSCC. It participates in the reconstitution of microtubule cytoskeleton, cell cycle progression and cell migration. Silencing STMN1 may affect the cell cycle progression, apoptosis, metastasis and chemoresistance of tumor cells.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4237.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable