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RAB0540

Sigma-Aldrich

Human FGF19 / Fibroblast Growth Factor 19 ELISA Kit

for serum, plasma, cell culture supernatants and urine

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32
Pricing and availability is not currently available.

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type urine
sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 30 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF19(9965)

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This Item
4307498.22261C9510
Pyrocatechol certified reference material, TraceCERT&#174;, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

50550

Pyrocatechol

Pyrocatechol purified by sublimation, &#8805;99.5%

430749

Pyrocatechol

Pyrocatechol for synthesis

8.22261

Pyrocatechol

Pyrocatechol &#8805;99%

C9510

Pyrocatechol

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

application(s)

-

application(s)

-

application(s)

-

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

format

neat

format

-

format

-

format

-

Quality Level

300

Quality Level

100

Quality Level

200

Quality Level

200

grade

certified reference material, TraceCERT®

grade

-

grade

-

grade

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

General description

This ELISA antibody pair detects human Fibroblast Growth Factor 19.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Fibroblast growth factor (FGF) 19 controls bile acid, fatty acid, glucose and phosphate metabolism in target organs by activating FGF receptor 4.[1][2] FGF19 regulates hepatic protein and glycogen metabolism via activation of insulin-independent endocrine pathway.[2] In diabetic mice, FGF19 reduces the levels of serum glucose and triglycerides.[2] Overexpression of the gene leads to the development of hepatocellular carcinoma (HCC).[3]

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
  • RABSTOP3ELISA Stop Solution (Item I)
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)
  • RABWASH420X Wash Buffer (Item B)

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0125J0390
    0825I0390
    0712I0390
    1205F0390
    1105F0390

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    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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    Christian Borup et al.
    The American journal of gastroenterology, 115(12), 2086-2094 (2020-08-03)
    The diagnosis of bile acid diarrhea is often missed because the availability of the seleno-taurohomocholic acid (SeHCAT) test is limited. We aimed to compare the biomarkers 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor 19 (FGF19) with the SeHCAT test. Patients with
    Lixia Gao et al.
    Oncogene, 38(13), 2394-2404 (2018-12-07)
    The fibroblast growth factor 19 gene FGF19 has previously been reported to be amplified in several cancer types and encodes for a key autocrine signaler known to promote tumorigenic growth. Thus, it is imperative to understand which cancers are oncogenically
    Xiangdong Zhao et al.
    Molecular carcinogenesis, 57(11), 1616-1625 (2018-08-04)
    Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19) gene are found in human breast cancer, mechanisms that contribute to such functional alterations remain elusive. We report here that high expression of FGF19 is associated with the
    Aze Wilson et al.
    Scientific reports, 10(1), 11725-11725 (2020-07-18)
    The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear receptors such as pregnane X receptor (PXR) and the multi-drug resistance protein
    FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
    Kir S, et al.
    Science, 331(6024), 1621-1624 (2011)
    View All Related Papers

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