S1763

Somatostatin

powder, BioReagent, suitable for cell culture

• Synonym(s): Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor
• Empirical Formula (Hill Notation): C₇₆H₁₀₄N₁₈O₁₉S₂
• CAS Number: 38916-34-6
• Molecular Weight: 1637.88
• Beilstein/REAXYS Number: 6436064
• EC Number: 254-186-5
• MDL number: MFCD00076762
• UNSPSC Code: 12352209
• PubChem Substance ID: 24899493
• NACRES: NA.77
• biological source: synthetic (organic)
• form: powder
• assay: ≥97% (HPLC)

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• product line: BioReagent
• assay: ≥97% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O

Description

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Application

Somatostatin has been used in cell culture. It has also been used in the study of glucose-6-phosphate dehydrogenase activity in monolayer cultures of thyroid epithelial cells.

Biochem/physiol Actions

Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Somatostatin (SST) is a peptide. It performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3–5).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 2 μg/ml stock solution, dissolve in 5 ml sterile culture medium per μg somatostatin.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)