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S1763

Sigma-Aldrich

Somatostatin

powder, BioReagent, suitable for cell culture

Synonym(s):

Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor

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About This Item

Empirical Formula (Hill Notation):
C76H104N18O19S2
CAS Number:
38916-34-6
Molecular Weight:
1637.88
Beilstein/REAXYS Number:
6436064
EC Number:
254-186-5
MDL number:
MFCD00076762
UNSPSC Code:
12352209
PubChem Substance ID:
24899493
NACRES:
NA.77
biological source:
synthetic (organic)
form:
powder
assay:
≥97% (HPLC)
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O

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antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

clone

1I18, recombinant monoclonal

clone

1I15, recombinant monoclonal

clone

1H18, recombinant monoclonal

clone

1N18, recombinant monoclonal

species reactivity

human, mouse

species reactivity

mouse, human

species reactivity

rat, human

species reactivity

human

technique(s)

affinity binding assay: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunocytochemistry: suitable, western blot: suitable

technique(s)

affinity binding assay: suitable, flow cytometry: suitable, immunocytochemistry: suitable, western blot: suitable

technique(s)

affinity binding assay: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

affinity binding assay: suitable, immunocytochemistry: suitable, western blot: suitable

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Application

Somatostatin has been used in cell culture.[1] It has also been used in the study of glucose-6-phosphate dehydrogenase activity in monolayer cultures of thyroid epithelial cells.[2]

Biochem/physiol Actions

Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Somatostatin (SST) is a peptide. It performs several functions like anti-proliferation, pro-apoptosis and anti-migration.[3] Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3–5).[4]

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 2 μg/ml stock solution, dissolve in 5 ml sterile culture medium per μg somatostatin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCD4470
    SLBX4440
    SLBV4368
    SLBR4538V
    SLBN9223V

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    The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that has a critical role in the regulation of glucose homeostasis, principally through the regulation of insulin secretion. The receptor system is highly complex, able to be activated
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