S1950

STX64

≥98% (HPLC)

• Synonym(s): 667 Coumate, BN 83495
• Empirical Formula (Hill Notation): C₁₄H₁₅NO₅S
• CAS Number: 288628-05-7
• Molecular Weight: 309.34
• MDL number: MFCD12912443
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824496
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1
• InChI: 1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
• InChI key: DSLPMJSGSBLWRE-UHFFFAOYSA-N
• Gene Information: human ... STS(412)

Description

Biochem/physiol Actions

STX64 is a potent, irreversible inhibitor of steroid sulfatase.

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC₅₀ = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)