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S4322

Sigma-Aldrich

Anti-Sirt6 (N-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

rat (predicted), mouse, human

packaging

antibody small pack of 25 μL

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Anti-Sirt6 (N-terminal) antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

S4322

Anti-Sirt6 (N-terminal) antibody produced in rabbit

Anti-Sirt6 (C-terminal) antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

S4197

Anti-Sirt6 (C-terminal) antibody produced in rabbit

Anti-Sirt1 (C-terminal) antibody produced in rabbit ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

S5322

Anti-Sirt1 (C-terminal) antibody produced in rabbit

Anti-SIRT1 antibody produced in rabbit ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

S5447

Anti-SIRT1 antibody produced in rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

UniProt accession no.

Q8N6T7

UniProt accession no.

Q8N6T7

UniProt accession no.

Q96EB6

UniProt accession no.

Q96EB6

General description

Sirtuin 6 (Sirt6) is a nuclear and chromatin-associated protein that belongs to the mammalian Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

Specificity

Anti-Sirt6 (N-terminal) recognizes human and mouse Sirt6. The detection of the Sirt6 band by immunoblotting is specifically inhibited with the immunizing peptide.

Immunogen

synthetic peptide corresponding to amino acids 19-33 of human Sirt6 via a C-terminal cysteine residue. The sequence is identical in mouse and differs by one amino acid in rat.

Application

Anti-Sirt6 (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Physical form

Solution in 0.01 M phosphate buffered, saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    098M4769V
    038M4829V
    037M4797V
    106M4819V
    076M4818V

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    Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
    Liszt G, et al.
    The Journal of Biological Chemistry, 280 (2005)
    Sergii Domanskyi et al.
    Apoptosis : an international journal on programmed cell death, 22(11), 1336-1343 (2017-09-01)
    Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we
    Differential expression of sirtuin family members in the developing, adult, and aged rat brain
    Sidorova-Darmos E, et al.
    Frontiers in Aging Neuroscience, 6 (2014)
    Justin W Nicholatos et al.
    Acta neuropathologica communications, 6(1), 120-120 (2018-11-10)
    Parkinson's disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in
    Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
    Mostoslavsky R, et al.
    Cell, 124 (2006)
    View All Related Papers

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