S6942

Staurosporine

from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor

• Synonym(s): Antibiotic AM-2282
• EC Number: 200-664-3
• MDL number: MFCD04041131
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered
• Quality Level: 300
• sterility: 0.2 μm filtered
• assay: >98% (HPLC)
• concentration: 1 mM in DMSO (100 μg/214 μL)
• technique(s): cell culture | mammalian: suitable
• antibiotic activity spectrum: fungi
• mode of action: enzyme | inhibits
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Chemical structure: indol derivative

Application

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.³ It was used to induce cell death in Jurkat cells.⁴

Biochem/physiol Actions

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.

Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)