S7936

SB 205384

solid

• Synonym(s): 4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester
• Empirical Formula (Hill Notation): C₁₇H₁₈N₂O₃S
• CAS Number: 160296-13-9
• Molecular Weight: 330.40
• MDL number: MFCD00918851
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278711
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 100
• color: off-white
• solubility: DMSO: 18 mg/mL; H₂O: insoluble
• SMILES string: CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
• InChI: 1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)
• InChI key: JDTZAGLGBRRCJT-UHFFFAOYSA-N

Description

Application

SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.⁶

Biochem/physiol Actions

GABA_A receptor modulator selective for the α₃β₂γ₂ subunit combination.

SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABA_A receptor.³ It affects the extrasynaptic GABA_A receptors in rat cortical neurons⁴ and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.⁵

Legal Information

Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)