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S8251

Sigma-Aldrich

Succinylcholine chloride dihydrate

98.0-102.0%, solid

Synonym(s):

Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride

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About This Item

Linear Formula:
[(CH3)3NCH2CH2OCOCH2]2Cl2 · 2H2O
CAS Number:
6101-15-1
Molecular Weight:
397.34
Beilstein/REAXYS Number:
3922827
EC Number:
200-747-4
MDL number:
MFCD00150564
UNSPSC Code:
41116107
PubChem Substance ID:
24277873
NACRES:
NA.77

Quality Level

100

assay

98.0-102.0%

form

solid

color

white

solubility

H2O: complete 100 mg/ml, clear to slightly hazy, colorless
H2O: soluble (unstable at pH > 9.)

originator

Novartis

SMILES string

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

InChI key

FFSBEIRFVXGRPR-UHFFFAOYSA-L

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Related Categories

Application

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.4,5

Biochem/physiol Actions

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.
Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.3

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Reconstitution

Solutions may be stored for several days at 4 °C.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP8101
MKCH8005
MKCC3936
MKBZ5191V
MKBW5278V

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William R Reed et al.
Experimental brain research, 225(2), 205-215 (2012-12-12)
Increasing our knowledge regarding intrafusal fiber distribution and physiology of paraspinal proprioceptors may provide key insights regarding proprioceptive deficits in trunk control associated with low back pain and lead to more effective clinical intervention. The use of vertebral movement as
J A Jeevendra Martyn et al.
Anesthesiology, 104(1), 158-169 (2006-01-06)
Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain
Berthold Drexler et al.
Chemico-biological interactions, 206(3), 555-560 (2013-07-11)
Intoxication with organophosphorus compounds is an important clinical problem worldwide. Although the core treatments - atropine, oximes and diazepam - are defined, high case fatalities were reported for intoxication with organophosphorus insecticides. In particular the role of oximes is not
Yumi Sato et al.
Journal of anesthesia, 27(1), 152-156 (2012-12-06)
Recent evidence suggests the possible development of difficult mask ventilation in patients with obstructive sleep apnea. Based on our current understanding of the pathophysiology of pharyngeal airway obstruction in obstructive sleep apnea patients, we conclude that anesthesiologists can decrease respiratory
Brandon H Cline et al.
BMC neuroscience, 13, 110-110 (2012-09-20)
A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of
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Global Trade Item Number

SKUGTIN
S8251-25G4061836960612
S8251-100G
S8251-250G
S8251-500G

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