SAB1300081
Anti-LRP1 (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-α-2-macroglobulin receptor, Anti-A2MR, Anti-Apolipoprotein E receptor, Anti-LRP, Anti-Low-density lipoprotein receptor-related protein 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.43
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General description
LRP1 (low density receptor protein 1) gene codes for a protein belonging to LDL receptor family. Lrp1 is known to be the largest mammalian endocytic receptor. The encoded protein is cysteine-rich and it is highly glycosylated. It is predominantly expressed in vascular smooth muscle cells, neurons, astrocytes, macrophages, hepatocytes, fibroblasts and malignant cells. The LDLRs (low-density lipoprotein receptors) have five domains namely repeated cysteine-rich regions of ligand-binding type and epidermal growth factor receptor-like repeats, YWTD (tyrosin, typrtophan, Threonine, aspartic) domains, a transmembrane domain, and a cytoplasmic tail that holds about three NPXY (asparagine-proline-X-tyrosine) motifs.
Immunogen
LRP1 (4520-4554)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.
Biochem/physiol Actions
LRP1 functions as a scavenger by internalizing several plasma components and also serves as a signaling molecule. Lrp1 is responsible for the transport of β-amyloid (Aβ) across the blood brain barrier, thereby contributing to the pathogenesis of Alzheimer′s disease. Lrp1 is normally associated with the cell membrane, but proteolytic cleavage of the cell results in its soluble form. Therefore, it loses its ability to endocytose and transport ligands. LRP1 is associated with a number of signaling pathways, such as mitogen-activated protein kinase (MAPK), serine/threonine protein kinase (AKT), insulin receptor (IR), extracellular signal-regulated kinase (ERK), and c-jun N-terminal kinase (JNK) pathways.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Joni M Prasad et al.
The Journal of biological chemistry, 291(35), 18430-18439 (2016-07-13)
The LDL receptor-related protein 1 (LRP1) is a large endocytic receptor that binds and mediates the endocytosis of numerous structurally diverse ligands. Currently, the basis for ligand recognition by LRP1 is not well understood. LRP1 requires a molecular chaperone, termed
Dong-Chuan Guo et al.
American journal of human genetics, 99(3), 762-769 (2016-08-30)
Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting. Although mutations in single genes can be used to identify at-risk individuals, the majority of dissection case
Patricia A Young et al.
The Journal of biological chemistry, 291(50), 26035-26044 (2016-10-31)
Hemophilia A is a bleeding disorder caused by a deficiency in coagulation factor VIII (fVIII) that affects 1 in 5,000 males. Current prophylactic replacement therapy, although effective, is difficult to maintain due to the cost and frequency of injections. Hepatic
B Shackleton et al.
Fluids and barriers of the CNS, 13(1), 14-14 (2016-08-10)
Transport across the blood-brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer's disease (AD). One of the receptors responsible for the transport of Aβ in the
Camilla De Nardis et al.
The Journal of biological chemistry, 292(3), 912-924 (2016-12-14)
LDL receptor-related protein 1 (LRP1) is a highly modular protein and the largest known mammalian endocytic receptor. LRP1 binds and internalizes many plasma components, playing multiple crucial roles as a scavenger and signaling molecule. One major challenge to studying LRP1
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