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Key Documents

SAB1405800

Sigma-Aldrich

Anti-Fas Antibody

mouse polyclonal

Synonym(s):

CD64, CD64A, FCRI, FLJ18345, IGFR1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Product Name

Anti-FCGR1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~42.6 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_000566.2

UniProt accession no.

P12314

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FCGR1A(2209)

General description

Fc fragment of IgG receptor Ia (FCGR1A) gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. (provided by RefSeq). Fc fragment of IgG receptor Ia (FCGR1A) gene is located on human chromosome 1q21.2. FCGR1A is expressed on monocytes and macrophages.

Immunogen

FCGR1A (NP_000557.1, 1 a.a. ~ 374 a.a) full-length human protein.

Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT

Biochem/physiol Actions

Fc fragment of IgG receptor Ia (FCGR1A) functions as the single high-affinity receptor of immunoglobulin G (IgG) in humans. It also regulates immune inflammation. FCGR1A acts as a diagnostic marker for bacterial infections, such as neonatal sepsis. FCGR1A is an important biomarker for rheumatoid arthritis (RA).

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
09244

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Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis.
Dai J, et al.
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University (2017)
FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway
Zhang H, et al.
Life Sciences (2018)
Elevated membrane and soluble CD64: a novel marker reflecting altered FcγR function and disease in early rheumatoid arthritis that can be regulated by anti-rheumatic treatment
Matt P, et al.
PLoS ONE, 10(9), e0137474-e0137474 (2015)
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR
Armengol G, et al.
Genomics, 95(4) (2010)
Kristina von Kietzell et al.
Journal of virology, 88(14), 8102-8115 (2014-05-09)
Despite its strong host tropism for erythroid progenitor cells, human parvovirus B19 (B19V) can also infect a variety of additional cell types. Acute and chronic inflammatory cardiomyopathies have been associated with a high prevalence of B19V DNA in endothelial cells

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