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SAB1409913

Anti-MYLK2 antibody produced in mouse

Name: Anti-MYLK2 antibody produced in mouse
Brand: SIGMA

purified immunoglobulin, buffered aqueous solution

Synonym(s):

KMLC, MLCK, MLCK2, skMLCK

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Pricing and availability is not currently available.

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 64.7 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

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This Item	SAB1411532	WH0085366M1	M7905
SAB1409913 Anti-MYLK2 antibody produced in mouse	SAB1411532 Anti-MYLK2 antibody produced in rabbit	WH0085366M1 Monoclonal Anti-MYLK2 antibody produced in mouse	M7905 Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form ascites fluid
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form -
UniProt accession no. Q9H1R3	UniProt accession no. Q9H1R3	UniProt accession no. Q9H1R3	UniProt accession no. -

General description

This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. (provided by RefSeq)

Immunogen

MYLK2 (NP_149109.1, 1 a.a. ~ 596 a.a) full-length human protein.

Sequence
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

11102

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Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

Li Zhu et al.

The Journal of biological chemistry, 288(44), 32050-32063 (2013-09-21)

Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellular clearance of amyloid-β (Aβ). Genetic down-regulation of

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.

Wanxia He, Yifeng Lu, Isam Qahwash, Xiang-You Hu, Ansi Chang, Riqiang Yan

Nature Medicine null

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

Fukumoto, H; Rosene, DL; Moss, MB; Raju, S; Hyman, BT; Irizarry, MC

The American Journal of Pathology null

7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.

Devi, L; Ohno, M

Neuropsychopharmacology null

Receptor tyrosine kinases positively regulate BACE activity and Amyloid-beta production through enhancing BACE internalization.

Zou, L; Wang, Z; Shen, L; Bao, GB; Wang, T; Kang, JH; Pei, G

Cell research null

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