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Key Documents

SAB1412470

Sigma-Aldrich

ANTI-RUNX1 antibody produced in mouse

clone 3A8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

AML1, AML1-EVI-1, AMLCR1, CBFA2, RUNX1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A8, monoclonal

form

buffered aqueous solution

mol wt

antigen 36.85 kDa

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable

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1.06521331058M1651
Sodium molybdate dihydrate for synthesis

8.43899

Sodium molybdate dihydrate

Sodium molybdate dihydrate ACS, Reag. Ph Eur, for analysis EMSURE®

1.06521

Sodium molybdate dihydrate

Sodium molybdate dihydrate ACS reagent, ≥99%

331058

Sodium molybdate dihydrate

Sodium molybdate dihydrate ≥99.5%, suitable for plant cell culture

M1651

Sodium molybdate dihydrate

form

crystals

form

crystals

form

powder or crystals

form

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

storage temp.

-

mp

687 °C (Elimination of water of crystallisation)

mp

687 °C (Elimination of water of crystallisation)

mp

100 °C (dec.) (lit.)

mp

100 °C (dec.) (lit.)

density

2.71 g/cm3 at 22 °C (for the dihydrate)

density

2.71 g/cm3 at 22 °C (for the dihydrate)

density

-

density

-

potency

4233 mg/kg LD50, oral (Rat)

potency

4233 mg/kg LD50, oral (Rat), >2000 mg/kg LD50, skin (Rat)

potency

-

potency

-

General description

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

Immunogen

RUNX1 (NP_001001890.1, 210 a.a. ~ 310 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFP

Biochem/physiol Actions

RUNX1 plays a vital role in tumour suppression and oncogenic activities.[1] In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    12174-S695
    07229-3A8

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    Kentson Lam et al.
    Frontiers in bioscience (Landmark edition), 17, 1120-1139 (2011-12-29)
    RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with
    Yu Fei Lee et al.
    PloS one, 9(9), e106661-e106661 (2014-09-05)
    The orchestration of histone modifiers is required to establish the epigenomic status that regulates gene expression during development. Whsc1 (Wolf-Hirschhorn Syndrome candidate 1), a histone H3 lysine 36 (H3K36) trimethyltransferase, is one of the major genes associated with Wolf-Hirshhorn syndrome

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