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Key Documents

SAB2101228

Sigma-Aldrich

Anti-KCNN2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-HSK2, Anti-KCNN2, Anti-KCa2.2, Anti-SK2, Anti-SKCA2

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About This Item

MDL number:
MFCD02097223
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

26 kDa

species reactivity

guinea pig, mouse, rabbit, dog, horse, human, rat, bovine

concentration

0.5 mg - 1 mg/mL

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This Item
EMU001631EMU008051EMU017491
MISSION® esiRNA targeting mouse Ddr1

EMU045291

MISSION® esiRNA

MISSION® esiRNA targeting mouse Cacybp

EMU001631

MISSION® esiRNA

MISSION® esiRNA targeting mouse Ddx1

EMU008051

MISSION® esiRNA

MISSION® esiRNA targeting mouse Ctnna1

EMU017491

MISSION® esiRNA

Gene Information

mouse ... DDR1(12305), Ddr1(12305)

Gene Information

mouse ... CACYBP(12301), Cacybp(12301)

Gene Information

mouse ... DDX1(104721), Ddx1(104721)

Gene Information

mouse ... CTNNA1(12385), Ctnna1(12385)

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Ensembl | mouse accession no.

ENSMUSG00000003534

Ensembl | mouse accession no.

ENSMUSG00000014226

Ensembl | mouse accession no.

ENSMUSG00000037149

Ensembl | mouse accession no.

ENSMUSG00000037815

esiRNA cDNA target sequence

TCTTCGGGTGGAGCTCTATGGCTGCCTCTGGCGGGATGGACTCCTGTCATATACAGCCCCCGTGGGGCAGACCATGCAGTTATCTGAGGTGATGGTACATCTCAATGATTCCACTTACGATGGATATACTGCTGGAGGGCTGCAGTATGGCGGTCTGGGCCAGCTGGCAGATGGCGTGGTGGGCCTGGATGATTTCAGGCAGAGCCAGGAGCTGCGGGTCTGGCCAGGCTATGACTATGTGGGATGGAGCAATCAGAGCTTCCCCACGGGCTACGTGGAGATGGAGTTTGAGTTTGATCGGTTGAGGACCTTCCAGACCATGCAGGTCCACTGTAACAACATGCACACTCTGGGAGCCCGCCTACCAGGTGGGGTGGAATGCCGGTTTAAAAGGGGTCCCGCCATGGCCTGGGAAGGAGAGCCTGTCCGCCATGCTCTGGGAGGCAGCCTTGGAGACCCCAGAGCCCGGGCCATCTCAGTGCCCCTGGGTGGCCACGTGGGCCGCTTTCTGCAGTGCAGATTCCTCTTTGCAGGTCCTTGGTTACTCTTCAGTGAGATCTCTTTCATCTCAGATGTGGTGAACGACTCCTCTG

esiRNA cDNA target sequence

CGATGATATGAAGCGAACCATTAATAAAGCGTGGGTGGAATCCAGAGAGAAGCAAGCCAGAGAAGACACGGAATTTTGAGGCTTTTAAAAGTCCGTATGGGAACTGTGATGTGGAATGCTCGTGTTCCAGTAAGGGGATGTTGTTGAACTGCACATATTTGTTCATGTGGGTATGTAGTTTTGACAGATAAATATTTACACCGCCTTTTAAGTAAAGATAGCAGATTCTCCATTTCTTACTGGAGGATTTGATTTAAATAAATAAGCTTATTAAACTGTTTCCTTCATTAGCACCCCAGACATTTCGTTTCAGAAAAGGCTATATGGCACTCTTACTGAAAATGTAAAAAGGAAGTCTTGCATAATGAAAATGTTATGTCACAGACTTTTGTTCTGGCTGGGA

esiRNA cDNA target sequence

GATCCTAGGAGGAGGGGATGTACTCATGGCTGCAGAAACAGGAAGTGGAAAAACTGGTGCATTTAGTATTCCCGTTATCCAGATAGTGTATGAAACTCTGAAAGACCAACAGGAAGGAAAGAAAGGGAAAACAACTATTAAAACTGGTGCTTCAGTGCTCAACAAGTGGCAGATGAACCCATATGATAGAGGGTCTGCTTTTGCAATTGGATCAGATGGTCTGTGTTGTCAGAGCAGAGAAGTGAAGGAGTGGCATGGATGCAGAGGAACTAGAGGACTGCTGAAAGGGAAGCACTACTATGAGGTGTCCTGTCATGACCAAGGGCTATGCAGAGTTGGGTGGTCTACCATGCAGGCTTCCTTAGACCTAGGTACTGACAAGTTTGGATTTGGCTTCGGTGGAACAGGAAAGA

esiRNA cDNA target sequence

TTTCCTGGAGACCAATGTCCCTCTATTAGTACTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAATATGCCCAAGTTTTTCGTGAACATGCCAACAAACTGATTGAGGTTGCCAACCTGGCCTGTTCAATCTCCAACAATGAAGAAGGCGTGAAGCTTGTCCGAATGTCTGCAAGCCAGTTAGAAGCGCTGTGTCCTCAGGTTATCAATGCTGCATTGGCGTTGGCAGCAAAGCCGCAGAGTAAACTGGCCCAAGAGAACATGGATCTTTTTAAAGAGCAATGGGAAAAGCAAGTCCGTGTTCTCACAGATGCTGTTGATGACATTACTTCCATCGATGACTTCTTGGCTGTCTCAGAGAACCACATTTTAGAAGATGTGAACAAGTGTGTTATTGCTCTCCAAGAGAAAGACGTGGATGGG

NCBI accession no.

NP_031610

NCBI accession no.

NM_009786

NCBI accession no.

NM_134040

NCBI accession no.

NM_009818

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Immunogen

Synthetic peptide directed towards the middle region of human KCNN2

Biochem/physiol Actions

KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Sequence

Synthetic peptide located within the following region: KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQ

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    QC4717

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    Yong-Chao Lu et al.
    The Journal of clinical endocrinology and metabolism, 99(10), 3800-3810 (2014-07-01)
    Small-conductance, Ca(2+)-activated K(+) channel 3 (SK3) has been shown to be expressed in porcine endometrium. However, the roles of SK3 in human endometrium during the menstrual cycle and early pregnancy are unknown. The objective of the study was to investigate

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