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SAB2108849

Sigma-Aldrich

Anti-PIEZO2 (N-terminal) antibody produced in rabbit HRP conjugated

affinity isolated antibody

Synonym(s):

GH, GH-N, GHN, IGHD1B, hGH-N

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.45

Pricing and availability is not currently available.

biological source

rabbit

conjugate

peroxidase conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

77 kDa

species reactivity (predicted by homology)

mouse, human, canine, rat, horse, bovine, guinea pig, rabbit

concentration

0.5 mg/mL

shipped in

wet ice

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This Item
SAB2108848HPA031975SAB2108846
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

peroxidase conjugate

conjugate

FITC conjugate

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

General description

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. ′Piezo′ comes from the Greek ′piesi,′ meaning ′pressure.′ The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.

Immunogen

Synthetic peptide directed towards the N-terminal region of Human PIEZO2

Sequence

Synthetic peptide located within the following region: VFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRK

Physical form

Supplied at 0.5 mg/ml in phosphate-buffered saline, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Henry Beetham et al.
    Scientific reports, 9(1), 12511-12511 (2019-08-31)
    The cell-cell adhesion protein E-cadherin (CDH1) is a tumor suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer (DGC) and lobular breast cancer (LBC). In
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    BMC cancer, 14, 552-552 (2014-08-01)
    E-cadherin is an adherens junction protein that forms homophilic intercellular contacts in epithelial cells while also interacting with the intracellular cytoskeletal networks. It has roles including establishment and maintenance of cell polarity, differentiation, migration and signalling in cell proliferation pathways.
    Nicola Bougen-Zhukov et al.
    Cancers, 14(7) (2022-04-13)
    The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for the cancer syndrome hereditary diffuse gastric cancer (HDGC). CDH1-deficient gastric cancers exhibit
    Lyvianne Decourtye-Espiard et al.
    Cancers, 14(1) (2022-01-12)
    Inactivating germline mutations in the CDH1 gene (encoding the E-cadherin protein) are the genetic hallmark of hereditary diffuse gastric cancer (HDGC), and somatic CDH1 mutations are an early event in the development of sporadic diffuse gastric cancer (DGC) and lobular

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