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SAB2501392

Anti-EPS8 (C-terminal) antibody produced in goat

Name: Anti-EPS8 (C-terminal) antibody produced in goat
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Epidermal growth factor receptor pathway substrate 8

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Pricing and availability is not currently available.

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, canine, human, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable

UniProt accession no.

Q12929

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This Item	SAB4500199	HPA037924	HPA037845
SAB1410151 Anti-STON1 antibody produced in rabbit	SAB4500199 Anti-STON1 antibody produced in rabbit	HPA037924 Anti-STN1 antibody produced in rabbit	HPA037845 Anti-STOX1 antibody produced in rabbit
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

General description

The gene EPS8 (epidermal growth factor receptor pathway substrate 8) is mapped to human chromosome 12p12. The protein has a phosphotyrosine-binding (PTB) domain at the N-terminal, an SH3 (src homology 3) domain and an effector domain at the C-terminal.[1]

Immunogen

Peptide with sequence SGVESFDEGSSH, from the C-terminal region of the protein sequence according to NP_004438.3

Biochem/physiol Actions

EPS8 (epidermal growth factor receptor pathway substrate 8) is a substrate for tyrosine kinases, such as epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and ERBB2 (erb-b2 receptor tyrosine kinase 2). In addition, it also interacts with the Src non-receptor tyrosine kinase. The protein is involved in Rac signaling and receptor endocytosis. It also regulates dendritic cell migration, morphogenesis of intestinal cells and microvilli, and stereocilia activity. It is upregulated in pancreatic cancer and oral squamous cell carcinoma.[1] Mutation in EPS8 is associated with autosomal recessive profound deafness.[2]

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Specification Sheet

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Certificates of Analysis (COA)

Lot/Batch Number

6081P1

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Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

Christina Schoenherr et al.

Journal of cell science, 127(Pt 24), 5303-5316 (2014-11-02)

Eps8 is an actin regulatory scaffold protein whose expression is increased in squamous cell carcinoma (SCC) cells. It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas

EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.

Asma Behlouli et al.

Orphanet journal of rare diseases, 9, 55-55 (2014-04-20)

Almost 90% of all cases of congenital, non-syndromic, severe to profound inherited deafness display an autosomal recessive mode of transmission (DFNB forms). To date, 47 causal DFNB genes have been identified, but many others remain to be discovered. We report

Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.

Wael M Abdel-Rahman et al.

World journal of gastroenterology, 18(29), 3896-3903 (2012-08-10)

To analyze the epidermal growth factor receptor pathway substrate 8 (EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells. We studied 8

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