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SAB2702069

Sigma-Aldrich

Anti-HHIP antibody produced in rabbit

Synonym(s):

HIP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

liquid

mol wt

79 kDa

species reactivity

chicken, human, mouse

concentration

0.86 mg/mL

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Show Differences

1 of 4

This Item
609099490997609277
Taurine-15N 98 atom % 15N, 98% (CP)

491330

Taurine-15N

L-Threonine-15N 98 atom % 15N, 98% (CP)

609099

L-Threonine-15N

Uric acid-1,3-15N2 98 atom % 15N

490997

Uric acid-1,3-15N2

4-Aminobutyric acid-15N 98 atom % 15N

609277

4-Aminobutyric acid-15N

mass shift

M+1

mass shift

M+1

mass shift

M+2

mass shift

M+1

assay

98% (CP)

assay

98% (CP)

assay

99% (CP)

assay

-

technique(s)

bio NMR: suitable, mass spectrometry (MS): suitable

technique(s)

bio NMR: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

solid

form

solid

form

solid

General description

The gene encoding HHIP (hedgehog interacting protein) is located on human chromosome 4 and encodes for a protein belonging to the hedgehog-interacting protein (HHIP) family.[1]

Immunogen

Recombinant fragment corresponding to a region within amino acids 263 and 554 of HHIP (Uniprot ID#Q96QV1)

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

Hedgehog interacting protein (HHIP) is highly conserved and interacts with all the three HH family members namely SHH (sonic hh), IHH (indian hh) and DHH (desert hh). It is also a vertebrate-specific inhibitor of HH signaling.[2] Single nucleotide polymorphisms in the HHIP gene are associated with increase in the risk of chronic obstructive pulmonary disease (COPD).[3]

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H412

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
GT40128-84

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The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, et al.
Bosnian Journal of Basic Medical Sciences / Udruzenje Basicnih Mediciniskih Znanosti = Association of Basic Medical Sciences, 18(1), 8-8 (2018)
Xiaobo Zhou et al.
Genomics, 101(5), 263-272 (2013-03-06)
Hedgehog interacting protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify genes regulated by HHIP, we performed gene expression microarray analysis in
Bo Wang et al.
Gene, 531(1), 101-105 (2013-09-03)
The hedgehog signaling pathway plays an important role in lung morphogenesis and cellular responses to lung injury. Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated the associations between HHIP polymorphisms and chronic obstructive pulmonary disease (COPD) and in

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