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Key Documents

SAB3500318

Sigma-Aldrich

Anti-TMEM16A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Ano1, Anti-Anoctamin 1, Anti-Calcium activated chloride channel, Anti-DOG1, Anti-TAOS1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_060513

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UFC40LG25UFC30GVUFC30DV00
Ultrafree® Centrifugal Filter, 2 mL Sample Volume pore size 0.22 μm, PVDF membrane (hydrophilic)

UFC40GV

Ultrafree® Centrifugal Filter, 2 mL Sample Volume

Ultrafree® Centrifugal Filter, 2 mL Sample Volume pore size 0.22 μm, PTFE membrane (hydrophilic)

UFC40LG25

Ultrafree® Centrifugal Filter, 2 mL Sample Volume

Ultrafree® Centrifugal Filter, 0.5 mL Sample Volume pore size 0.22 μm, PVDF membrane (hydrophilic)

UFC30GV

Ultrafree® Centrifugal Filter, 0.5 mL Sample Volume

Ultrafree® Centrifugal Filter, 0.5 mL Sample Volume pore size 0.65 μm, PVDF membrane (hydrophilic)

UFC30DV00

Ultrafree® Centrifugal Filter, 0.5 mL Sample Volume

material

PVDF membrane (hydrophilic), polypropylene

material

PTFE membrane (hydrophilic), polypropylene

material

PVDF membrane (hydrophilic), polypropylene

material

PVDF membrane (hydrophilic), polypropylene

parameter

2 mL sample volume, 50 °C max. temp.

parameter

2 mL sample volume, 50 °C max. temp.

parameter

0.5 mL sample volume, 50 °C max. temp.

parameter

0.5 mL sample volume, 50 °C max. temp.

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

manufacturer/tradename

Ultrafree®

manufacturer/tradename

Ultrafree®

manufacturer/tradename

Ultrafree®

manufacturer/tradename

Ultrafree®

pore size

0.22 μm pore size

pore size

0.22 μm pore size

pore size

0.22 μm pore size

pore size

0.65 μm pore size

feature

holdup volume 10 μL

feature

holdup volume 10 μL

feature

holdup volume 5 μL

feature

holdup volume 5 μL

General description

Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.

Immunogen

TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.

Biochem/physiol Actions

Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500318.

Physical form

Supplied in PBS with 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    54190904

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    EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
    Strege PR
    American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
    TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
    Kulkarni S
    Genes Chromosomes Cancer (2017)
    GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
    Masuko K
    American Journal of Human Genetics (2004)
    Meiyan Sun et al.
    Endocrinology, 155(8), 2787-2796 (2014-05-16)
    Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and
    Xuan-Yu Wang et al.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(9), 1298-1310 (2014-07-22)
    Interstitial cells of Cajal associated with the submuscular plexus (ICC-SMP) generate omnipresent slow-wave activity in the colon and are associated with prominent motor patterns. Our aim was to investigate colon motor dysfunction in W/W(v) mice in which the ICC are

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