SAB4200650
Monoclonal Anti-SH3GL1 (C-terminal) antibody produced in mouse
clone Ep2.17, purified from hybridoma cell culture
Synonym(s):
Anti-CNSA1, Anti-EEN, Anti-SH3D2B, Anti-SH3P8
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Ep2.17, monoclonal
form
buffered aqueous solution
mol wt
~41 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
flow cytometry: 2-5 μg/test using using HeLa cells.
immunoblotting: 1-2 μg/mL using whole extracts of HeLa.
Related Categories
General description
Monoclonal Anti-SH3GL1 (C-terminal) (mouse IgG2b isotype) is derived from the hybridoma Ep2.17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. SH3GL1 (SH3-domain GRB2-like 1), also known as endophilin-A2, is a member of the endophilin family of Src homology 3 (SH3) domain-containing proteins. The SH3 domain drives protein-protein interactions through binding to proline-rich ligands. The SH3GL proteins have a novel N-terminal segment, and a peculiar tissue distribution: SH3GL1 is ubiquitous, SH3GL2 located in the brain, and SH3GL3 in brain and testis.
Immunogen
a synthetic peptide corresponding to a sequence at the C-terminal region of human SH3GL1
Application
Monoclonal Anti-SH3GL1 (C-terminal) antibody produced in mouse has been used in immunoblotting and flow cytometry.
Biochem/physiol Actions
SH3GL1 is involved in several brain tumors, such as glioma, where its levels were increased in proportion to the tumor progression. In cells generated from children malignant brain tumor medulloblastoma (MB), SH3GL1 expression was found to be regulated by the miRNA, miR-218.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Endophilin A2: a potential link to adiposity and beyond
Alfadda AA, et al.
Molecules and cells, 40(11), 855-855 (2017)
Jipeng Shi et al.
Molecular medicine reports, 8(4), 1111-1117 (2013-08-24)
An increasing number of studies have suggested that microRNAs (miRNAs) are aberrantly expressed in numerous types of tumors and that a deregulation in miRNA expression may lead to carcinogenesis. Although miR‑218 has been demonstrated to be downregulated in several types
G Cestra et al.
The Journal of biological chemistry, 274(45), 32001-32007 (1999-11-05)
The proline-rich domain of synaptojanin 1, a synaptic protein with phosphatidylinositol phosphatase activity, binds to amphiphysin and to a family of recently discovered proteins known as the SH3p4/8/13, the SH3-GL, or the endophilin family. These interactions are mediated by SH3
C Giachino et al.
Genomics, 41(3), 427-434 (1997-05-01)
The Src-homology-3 domain (SH3) is an evolutionarily conserved, 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. The SH3 drives protein-protein interactions through binding to proline-rich
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