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SAB4200663

Sigma-Aldrich

Anti-Copeptin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CT-proAVP

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

200

antibody form

affinity isolated antibody

antibody product type

primary antibodies

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunoblotting: 0.25-0.5  μg/mL (recommended using recombinant human Copeptin trifluoroacetate)
immunohistochemistry: 20 μg/mL (recommended using mouse or human kidney sections)
immunoprecipitation (IP): 5-10 μg (recommended using recombinant human Copeptin trifluoroacetate (C8749).)
indirect ELISA: 0.25-0.5  μg/mL (recommended using human Copeptin trifluoroacetate (C8749) for coating.)

UniProt accession no.

P01185

shipped in

dry ice

storage temp.

−20°C

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Show Differences

1 of 4

This Item
609099490997609277
Taurine-15N 98 atom % 15N, 98% (CP)

491330

Taurine-15N

L-Threonine-15N 98 atom % 15N, 98% (CP)

609099

L-Threonine-15N

Uric acid-1,3-15N2 98 atom % 15N

490997

Uric acid-1,3-15N2

4-Aminobutyric acid-15N 98 atom % 15N

609277

4-Aminobutyric acid-15N

mass shift

M+1

mass shift

M+1

mass shift

M+2

mass shift

M+1

assay

98% (CP)

assay

98% (CP)

assay

99% (CP)

assay

-

technique(s)

bio NMR: suitable, mass spectrometry (MS): suitable

technique(s)

bio NMR: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 15N

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

solid

form

solid

form

solid

General description

AVP or pre-proAVP, also known as, vasopressin-neurophysin 2-copeptin is one of the main hormones of the axis hypothalamic-pituitary adrenal. It is split into 3 chains: Arg-vasopressin, neurophysin-2 and copeptin. Copeptin is a glycopeptide with 39 amino acids, located at the C-terminal part of the pre-proAVP. It is secreted by the posterior pituitary gland and poured into the systemic circulation.
The gene AVP (arginine vasopressin) is mapped to human chromosome 20. It is an antidiurectic hormone which is produced by hypothalamic neurons.

Immunogen

a synthetic peptide corresponding to the C-terminal region of human Copeptin

Application

Anti-Copeptin antibody produced in rabbit has been used in various immunochemical techniques including :
  • immunohistochemistry
  • immunoblotting
  • immunoprecipitation
  • enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Copeptin concentration directly reflects AVP activation and serves as a biomarker of the AVP system. Altered copeptin levels are implicated in stroke, sudden death and cardiovascular events. It can also be used as a biomarker for a list of illnesses, such as acute myocardial infarction (AMI), vasodilatory shock, metabolic syndrome, diabetes insipidus, diabetes mellitus, sepsis, septic shock, lower respiratory tract infections, hyponatremia, acute dyspnea, autosomal dominant polycystic kidney disease (ADPKD), intracerebral hemorrhage, pulmonary arterial hypertension (PAH) and head injury.
The gene AVP (arginine vasopressin) encodes preprovasopressin which is processed into vasopressin, neurophysin II and glycoprotein (copeptin). Mutations in it are associated with neurohypophyseal diabetes insipidus. It also plays a crucial role in social mannerism, such as recognition, aggression, reproduction and parenting. The levels of circulating copeptin is higher in children suffering from febrile seizures.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
075M4848V

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Copeptin and its potential role in diagnosis and prognosis of various diseases
Dobvsa L and Cullen EK
Biochemical Medicine, 23(2), 172-190 (2013)
Jia Jia Liu et al.
PloS one, 10(8), e0136436-e0136436 (2015-08-22)
Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress. Here, the relationships between AVPR1A RS3, early-life stressors, and social
Nils P Nickel et al.
Respiratory research, 14, 130-130 (2013-11-21)
To determine the levels of circulating copeptin in patients with pulmonary arterial hypertension (PAH), and to evaluate its relation with disease severity, outcome and response to treatment. Vasopressin is a key regulator of body fluid homeostasis. The co-secreted protein copeptin
Wiebke Fenske et al.
Journal of the American Society of Nephrology : JASN, 22(4), 782-790 (2011-03-19)
In ESRD, the neurohormone arginine vasopressin (AVP) may act primarily through V1a and V1b receptors, which promote vasoconstriction, myocardial hypertrophy, and release of adrenocorticotropic hormone. The preanalytical instability of AVP limits the investigation of whether this hormone associates with cardiovascular
Benjamin Stöcklin et al.
PloS one, 10(4), e0124663-e0124663 (2015-04-22)
Accurate diagnosis of febrile seizures in children presenting after paroxysmal episodes associated with fever, is hampered by the lack of objective postictal biomarkers. The aim of our study was to investigate whether FS are associated with increased levels of serum
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