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SAB4200718

Sigma-Aldrich

Anti-Elastin antibody, Mouse monoclonal

clone BA-4, purified from hybridoma cell culture

Synonym(s):

Anti-ELN, Anti-Tropoelastin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

Quality Level

200

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

BA-4, monoclonal

form

buffered aqueous solution

species reactivity

sheep, hamster, bovine, goat, frog, rabbit, porcine, human, guinea pig, canine

concentration

~1.0 mg/mL

technique(s)

immunoblotting: suitable
immunohistochemistry: 10-20 μg/mL using enzyme-retrieved formalin-fixed, paraffin-embedded sheep arterial tissue sections
immunoprecipitation (IP): suitable

isotype

IgG1

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General description

Anti-Elastin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the BA-4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with bovine alpha-Elastin.

Immunogen

bovine alpha-Elastin

Application

Anti-Elastin antibody, Mouse monoclonal has been used in:
  • immunohistochemistry
  • immunoblot
  • immunoprecipitation

Biochem/physiol Actions

Elastin (ELN) provides elasticity and is integrated with other proteins from the ECM in elastic fibrils. Elastin undergoes changes of morphology with aging and at many disease states. In addition, several heritable diseases, such as supravalvular aortic stenosis, cutis laxa, Marfan syndrome, pseudoxanthoma elasticum and Buschke-Ollendorf syndrome, may result from molecular defects of elastin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
017M4760V
51161004

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Elastin
Biochemistry of Collagens, Laminins and Elastin, 197-201 (2016)
Elastic fibres in health and disease
Baldwin AK, et al.
Expert Reviews in Molecular Medicine, 15 (2013)
Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly
Hinek A and Wilson SE
The American Journal of Pathology, 156(3), 925-938 (2000)
Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis.
Krettek A, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 23(4), 582-587 (2003)

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