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SAB4200746

Sigma-Aldrich

Anti-α-Fetoprotein (AFP) antibody, Mouse monoclonal

clone C3, purified from hybridoma cell culture

Synonym(s):

Anti-AFP, Anti-Alpha-1-fetoprotein, Anti-Alpha-fetoglobulin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

C3, monoclonal

form

buffered aqueous solution

mol wt

~74 kDa

species reactivity

human, canine, porcine

concentration

~1.0 mg/mL

General description

The gene encoding α-fetoprotein (AFP) is localized on human chromosome 4. It encodes a plasma glycoprotein that has a molecular mass of 70kDa. It is synthesized along with serum albumin during the development of embryonic yolk sac and the liver.

Immunogen

Purified human α-fetoprotein

Biochem/physiol Actions

α-fetoprotein (AFP) is involved in the regulation of fatty acids in both fetal and proliferating adult liver cells. Its expression is found to be increased in acute liver injuries, indicating active liver regeneration. AFP has been associated with fatty liver disease (FLD), a disease that may lead to cirrhosis and hepatocellular carcinoma. It serves as a tumor marker for HCC (hepatocellular carcinoma).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

Store at –20°C. For continuous use, store at 2–8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Other Notes

In order to obtain best results in different techniques and preparations, we recommend determining optimal working concentration by titration test.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
037M4760V
51170105

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Association between serum alpha-fetoprotein levels and fatty liver disease: a cross-sectional study.
Xu P, et al.
World Journal of Gastrointestinal Oncology (2014)
S Kate Alldred et al.
The Cochrane database of systematic reviews, (12), CD011984-CD011984 (2015-12-15)
Down's syndrome occurs when a person has three copies of chromosome 21, or the specific area of chromosome 21 implicated in causing Down's syndrome, rather than two. It is the commonest congenital cause of mental disability and also leads to
Evaluation of alpha-fetoprotein in detecting hepatocellular carcinoma recurrence after radiofrequency ablation.
Siripongsakun S, et al.
Journal of Gastroenterology and Hepatology (2014)
Clinical significance of elevated serum alpha-fetoprotein (AFP) level in acute viral hepatitis A (AHA).
Seo SI, et al.
Hepato-Gastroenterology (2013)
Bérénice Charrière et al.
World journal of hepatology, 8(21), 881-890 (2016-08-02)
Alpha-fetoprotein (AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma (HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its
View All Related Papers

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