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SAB4300159

Sigma-Aldrich

Anti-phospho-SMC1A (pSer957) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CDLS2 antibody produced in rabbit, Anti-DKFZp686L19178 antibody produced in rabbit, Anti-DXS423E antibody produced in rabbit, Anti-KIAA0178 antibody produced in rabbit, Anti-structural maintenance of chromosomes 1A antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~145 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-S-SP-Q-G)

NCBI accession no.

NP_006297.2

UniProt accession no.

Q14683

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer957)

Gene Information

human ... SMC1A(8243)

Immunogen

Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G), according to the protein SMC1A.

Features and Benefits

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Target description

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
871511198

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