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Key Documents

SAB4300238

Sigma-Aldrich

Anti-phospho-NFKBIB (pSer23) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-IKBB antibody produced in rabbit, Anti-TRIP9 antibody produced in rabbit, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~48 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

isotype

IgG

immunogen sequence

(L-G-SP-L-G)

NCBI accession no.

NP_001001716.1

UniProt accession no.

Q15653

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer23)

Gene Information

human ... NFKBIB(4793)

Immunogen

Peptide sequence around phosphorylation site of serine 23 (L-G-S(p)-L-G), according to the protein NFKBIB.

Features and Benefits

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Target description

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951411304

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