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Key Documents

SAB4300575

Sigma-Aldrich

Anti-AKT1 (Ab-450) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-AKT antibody produced in rabbit, Anti-MGC99656 antibody produced in rabbit, Anti-PKB antibody produced in rabbit, Anti-PKB-ALPHA antibody produced in rabbit, Anti-v-akt murine thymoma viral oncogene homolog 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD03096597
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~60 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

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pore size

0.45 μm

pore size

1.0 μm

pore size

0.2 μm

pore size

0.2 μm

material

PTFE membrane, polypropylene housing

material

PTFE membrane, polypropylene housing

material

PTFE membrane, polypropylene housing

material

PTFE membrane, polypropylene housing

manufacturer/tradename

Millex™

manufacturer/tradename

Millex™

manufacturer/tradename

Millex™

manufacturer/tradename

Millex™

diam.

50 mm

diam.

50 mm

diam.

50 mm

diam.

50 mm

fitting

inlet stepped hose barb (with Female Luer slip interior), outlet stepped hose barb (with Female Luer slip interior)

fitting

inlet stepped hose barb (with Female Luer slip interior), outlet stepped hose barb (with Female Luer slip interior)

fitting

inlet/outlet hose barb (1/2 in.-1/4 in., with Female Luer slip interior)

fitting

inlet stepped hose barb (with Female Luer slip interior), outlet stepped hose barb (with Female Luer slip interior)

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

Immunogen

Peptide sequence around aa. 448-452 (T-I-T-P-P), according to the protein AKT1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951421502

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