SAB4500090

Anti-ADARB1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase
• MDL number: MFCD02686608
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 80 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI accession no.: P78563
• UniProt accession no.: P78563
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ADARB1(104)

Description

General description

Adenosine deaminase, RNA specific B1 (ADARB1) is encoded by the gene mapped to human chromosome 21q22.3, a region associated with familial bipolar disorder. ADARB1 is characterized with two double-stranded RNA-binding domains and a deaminase domain involved in editing action.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADARB1.

Immunogen Range: 481-530

Biochem/physiol Actions

Adenosine deaminase, RNA specific B1 (ADARB1) enzyme plays a vital role in editing pre-mRNA of glutamate receptor B subunit. Combined effect of ADARB1 and HTR2C (5-Hydroxytryptamine Receptor 2C) variants contribute to the suicide attempt (SA) vulnerability in psychiatric patients. ADARB1 is a candidate gene for neurological diseases, such as bipolar affective disorder and epilepsy. Decrease in the activity of ADAR2 enzyme results in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated death of motor neurons in mice. ADARB1 enzyme is expressed consistently in carcinomas and sarcomas, and it is upregulated in lymphomas and seminomas when compared to normal tissues.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable