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Key Documents

SAB4501977

Sigma-Aldrich

Anti-NF1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Neurofibromatosis-related protein NF-1, Neurofibromin

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About This Item

MDL number:
MFCD02264160
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 319 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

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grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical

agency

traceable to USP 1457888

agency

traceable to USP 1367606

agency

traceable to USP 1133966

agency

traceable to USP 1457877

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

CofA

current certificate can be downloaded

packaging

pkg of 100 mg

packaging

pkg of 50 mg

packaging

pkg of 100 mg

packaging

pkg of 150 mg

storage temp.

-10 to -25°C

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

General description

Anti-NF1 Antibody detects endogenous levels of total NF1 protein.
NF1 (neurofibromin 1) gene is mapped to human chromosome 17q11.2. The protein encoded contains more than 2800 amino acids.

Immunogen

The antiserum was produced against synthesized peptide derived from human NF1.

Immunogen Range: 1551-1600

Biochem/physiol Actions

NF1 (neurofibromin 1) is a tumor suppressor gene and negatively regulates RAS (proto-oncogene, GTPase). Mutation in NF1 is strongly associated with the pathogenesis of melanoma and also causes neurofibromatosis type 1. Loss of NF1 allele results in benign neurofibromas in nonmyelinating Schwann cell and is associated with desmoplastic melanoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    3113094

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    Updated nomenclature for human and mouse neurofibromatosis type 1 genes.
    Corina Anastasaki et al.
    Neurology. Genetics, 3(4), e169-e169 (2017-08-15)
    Helena Cirenajwis et al.
    Molecular oncology, 11(4), 438-451 (2017-03-08)
    In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most
    D H Ki et al.
    Oncogene, 36(8), 1058-1068 (2016-08-02)
    Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, frequently metastatic sarcomas that are associated with neurofibromatosis type 1 (NF1), a prominent inherited genetic disease in humans. Although loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency
    Tao Sun et al.
    The Journal of clinical investigation, 124(9), 4123-4133 (2014-08-02)
    The prevalence of brain tumors in males is common but unexplained. While sex differences in disease are typically mediated through acute sex hormone actions, sex-specific differences in brain tumor rates are comparable at all ages, suggesting that factors other than

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