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Key Documents

SAB4502055

Sigma-Aldrich

Anti-OVOL1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

OVOL1, Putative transcription factor Ovo-like 1, hOvo1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 30 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

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Anti-SLC25A4 affinity isolated antibody

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Anti-SLC25A4

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Gene Information

human ... GABARAPL1(23710)

Gene Information

human ... GABARAPL1(23710)

Gene Information

human ... SLC25A28(81894)

Gene Information

human ... SLC25A4(291)

species reactivity

horse, bovine, dog, mouse, rat, guinea pig, rabbit, human

species reactivity

human

species reactivity

mouse, rabbit, dog, human, bovine, horse, rat, guinea pig

species reactivity

dog, guinea pig, bovine, mouse, human, rabbit, rat, sheep, goat

General description

Anti-OVOL1 antibody detects endogenous levels of total OVOL1 protein.
The OVOL1 (ovo like transcriptional repressor 1) gene is mapped to human chromosome 11q13.1. It is widely conserved. In mammals, the gene encodes for C2H2 zinc finger transcription factor. It is predominantly expressed in the human placenta and in the inner root sheath of the hair follicle, suprabasal layer of the epidermis, the ductal portion of the eccrine glands and mature sebocytes of the skin.{36] The protein is localized to cytoplasm.

Immunogen

The antiserum was produced against synthesized peptide derived from human OVOL1.

Immunogen Range: 1-50

Biochem/physiol Actions

The protein encoded by the OVOL1 (ovo like transcriptional repressor 1) gene regulates proliferation and differentiation of epithelial cells. This protein is homologous to that in Drosophila species, which regulates trophoblast differentiation. OVOL1 is known to take part in epidermal keratinisation by inducing differentiation. OVOL1 is associated with atopic dermatitis. OVOL1 is associated with skin morphogenesis and tumorigenesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    3110046

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.
    Ito T
    The American Journal of Pathology, 186(4), 1036-1043 (2016)
    OVO-like 1 regulates progenitor cell fate in human trophoblast development.
    Renaud SJ
    Proceedings of the National Academy of Sciences of the USA, 112(45), E6175-E6184 (2015)
    Chikage Mitoma et al.
    Fukuoka igaku zasshi = Hukuoka acta medica, 105(8), 166-173 (2014-12-17)
    OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although
    High density genotyping study identifies four new susceptibility loci for atopic dermatitis
    David Ellinghaus
    Nature Genetics, 45(7), 808-812 (2013)

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