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Key Documents

SAB4503924

Sigma-Aldrich

Anti-phospho-IR (pTyr1355) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 156 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P06213

UniProt accession no.

P06213

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr1355)

Gene Information

human ... INSR(3643)

General description

Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.

Immunogen

The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.

Immunogen Range: 1326-1375

Biochem/physiol Actions

Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
110493

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Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
Pechlivanis S, et al.
Endocrine-Related Cancer, 14(3), 733-740 (2007)
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
Xu X, et al.
Reproductive Biology and Endocrinology, 9(1), 76-76 (2011)
Sequencing analysis of insulin receptor defects and detection of two novel mutations in INSR gene.
Ardon O, et al.
Molecular genetics and metabolism reports, 1, 71-84 (2014)
A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS.
Jin L, et al.
Molecular Human Reproduction, 12(3), 151-155 (2006)

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