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SAB4504264

Sigma-Aldrich

Anti-phospho-RAD51 (pTyr315) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

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This Item
1166309307408.22011
Dehydroacetic acid Pharmaceutical Secondary Standard; Certified Reference Material

PHR1582

Dehydroacetic acid

Dehydroacetic acid United States Pharmacopeia (USP) Reference Standard

1166309

Dehydroacetic acid

Dehydroacetic acid ≥98.0% (T)

30740

Dehydroacetic acid

Dehydroacetic acid for synthesis

8.22011

Dehydroacetic acid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

format

neat

format

neat

format

-

format

-

Quality Level

300

Quality Level

-

Quality Level

100

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

-

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

2-30°C

General description

RAD51 (RAD51 recombinase) belongs to the RecA/RadA/Rad51 protein family. It has a conserved ATP binding core. This protein is expressed in testis, ovary, and lymphoid tissue. It is located on human chromosome 15q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Tyr315.

Immunogen Range: 281-330

Application

Anti-phospho-RAD51 (pTyr315) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

RAD51 (RAD51 recombinase) plays a major role in homology-directed repair (HDR) and cell viability.This gene acts an an important target for cancer therapy. RAD51 interacts with BRCA2 (breast cancer susceptibility protein) and participates in DSB (double strand DNA breaks) repair.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    111117

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    A cell-penetrating antibody inhibits human RAD51 via direct binding
    Turchick A, et al.
    Nucleic Acids Research, 45(20), 11782-11799 (2017)
    Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability
    Mirza S, et al.
    Cell Cycle, 11(22), 4266-4274 (2012)
    Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro.
    Baumann P, et al.
    Cell, 87(4), 757-766 (1996)
    RAD51, BRCA2 and DNA repair: a partial resolution.
    Lord CJ and Ashworth A
    Nature Structural and Molecular Biology, 14(6), 461-462 (2007)
    The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity.
    Galkin VE, et al.
    Structure, 14(6), 983-992 (2006)
    View All Related Papers

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