SAB4504648
Anti-phospho-Trk C (pTyr516) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 94 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr516)
Gene Information
human ... NTRK3(4916)
General description
Neurotrophic receptor tyrosine kinase 3 (NTRK3), also known as tropomyosin receptor kinase C (TRKC), with 20 exons and 19 introns, is mapped to human chromosome 15q25. NTRK3 encodes the high-affinity receptor for neurotrophin 3 (NT-3). The encoded 145kDa glycoprotein belongs to tropomyosin-related kinase (Trk) family of neurotrophin receptors. NTRK3 is characterized with a signal sequence, two cysteine-rich domains flanking a leucine-rich domain, two Ig-like domains of the C2 type, a transmembrane domain and a tyrosine kinase domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516.
Immunogen Range: 482-531
Immunogen Range: 482-531
Biochem/physiol Actions
Neurotrophic receptor tyrosine kinase 3 (NTRK3) plays a vital role in regulation of cell proliferation, survival and differentiation in the mammalian nervous system, especially those of sensory neurons involved in proprioception. It is also involved in the formation of the mammalian heart. TRKC facilitates initiation, progression and metastasis of many tumors in humans. TRKC is overexpressed in neuroblastomas as well as medulloblastomas and also in various non-neuronal tissues including medullary thyroid carcinoma, breast cancer, colon cancer, lung cancer, liver cancer, prostate cancer. The encoded protein acts as a receptor for the neurotrophin 3′-nucleotidase (NT3), which is involved in oligodendrocyte and myelin formation. Variation in the gene affects white matter integrity in brain regions associated with neuropsychiatric disorders, including major depressive disorder (MDD-RE). TRKC stimulates the expression of serine/threonine-protein kinase PLK-1 and Twist-1 transcription factor via activation of Akt (a serine/threonine kinase also known as protein kinase B [PKB]) / mammalian (or mechanistic) target of rapamycin (mTOR) pathway and inhibits apoptosis. Thus, it facilitates leukemogenesis.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Min Soo Kim et al.
Molecules and cells, 36(2), 177-184 (2013-07-09)
It has been suggested that activation of receptor PTKs is important for leukemogenesis and leukemia cell response to targeted therapy in hematological malignancies including leukemia. PTKs induce activation of the PI3K/Akt/mTOR pathway, which can result in prevention of apoptosis. Here
Meredith N Braskie et al.
NeuroImage, 82, 146-153 (2013-06-04)
The NTRK3 gene (also known as TRKC) encodes a high affinity receptor for the neurotrophin 3'-nucleotidase (NT3), which is implicated in oligodendrocyte and myelin development. We previously found that white matter integrity in young adults is related to common variants
Ranjana Verma et al.
Biological psychiatry, 63(12), 1185-1189 (2008-03-28)
We reported genome-wide significant linkage on chromosome 15q25.3-26.2 to recurrent early-onset major depressive disorder (MDD-RE). Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene. In
N Ichaso et al.
Oncogene, 17(14), 1871-1875 (1998-10-20)
The trkC gene encodes the high-affinity receptor for neurotrophin 3 and plays an important role in the regulation of the survival and differentiation of the mammalian nervous system and in heart development. Chromosomal rearrangements of trkC have been recently reported
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