SAB4700059
Monoclonal Anti-CD4 , (N-terminal) antibody produced in mouse
clone MEM-241, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-CD4mut, Anti-IMD79, Anti-OKT4D
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-241, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
1 of 4
This Item | C3915 | C9754 | PHR1764 |
|---|---|---|---|
| assay ≥94% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay - |
| form powder | form powder | form powder | form - |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| storage temp. 10-30°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| storage condition OK to freeze, protect from light | storage condition - | storage condition - | storage condition - |
General description
CD4 (cluster of differentiation 4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.
Immunogen
2 N-terminal domains of human CD4 fused to human IgG1 Fc
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
CD4 (cluster of differentiation 4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for HIV-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.
Beckham JC
Journal of clinical immunology, 12, 353-361 (1992)
Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2.
Owen GR
Biochemistry, 55, 2227-2237 (2016)
The role of CD4 on mechanical properties of live cell membrane.
Bui VC and Nguyen TH
Journal of Biomedical Materials Research Part A, 104, 239-244 (2016)
Isochromosomes 12p and 9p: parental origin
and possible mechanisms of formation
Dutly F
European Journal of Human Genetics, 6, 140-144 (1998)
Kouichi Furugaki et al.
PloS one, 9(7), e101854-e101854 (2014-07-12)
Polyplex micelles have demonstrated biocompatibility and achieve efficient gene transfection in vivo. Here, we investigated a polyplex micelle encapsulating genes encoding the tumor-associated antigen squamous cell carcinoma antigen recognized by T cells-3 (SART3), adjuvant CD40L, and granulocyte macrophage colony-stimulating factor
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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