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Key Documents

SAB4700541

Sigma-Aldrich

Anti-CD261, low endotoxin antibody, Mouse monoclonal

clone DR-4-02, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-DR4, Anti-TNFRSF10A, Anti-TRAIL-R1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DR-4-02, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable

impurities

≤1 EU/μg endotoxin (LAL test)

isotype

IgG1

NCBI accession no.

NM_003844.3

UniProt accession no.

O00220

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... TNFRSF10A(8797)

Related Categories

General description

The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.

Immunogen

Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 3-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
527868
H49K

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Shu Yang et al.
Oncology letters, 11(6), 4167-4176 (2016-06-18)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. However, the potential use of TRAIL in the treatment of cancer is limited by the inevitable emergence of drug resistance.
Sárka Símová et al.
Apoptosis : an international journal on programmed cell death, 13(3), 423-436 (2008-01-01)
TRAIL, a ligand of the TNFalpha family, induces upon binding to its pro-death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5 the apoptosis of cancer cells. Activated receptors incite the formation of the Death-Inducing Signaling Complex followed by the activation of the downstream apoptotic

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