SAB4702054

Monoclonal Anti-CD56 PerCP produced in mouse

• Synonym(s): MSK39, NCAM1
• UNSPSC Code: 12352203

Properties

• conjugate: Peridinin-Chlorophyll-Protein Complex conjugate
• Quality Level: 100
• antibody product type: primary antibodies
• clone: MEM-188, monoclonal
• form: buffered aqueous solution
• species reactivity: (Non-human primates), ( Human)
• technique(s): flow cytometry: suitable
• isotype: IgG2a
• UniProt accession no.: P13591
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... NCAM1(4684)

Description

General description

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.

Specificity

The antibody MEM-188 reacts with an extracellular epitope on a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody MEM-188 could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.

Immunogen

KG-1 human acute myelogenous leukemia cell line

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Storage and Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable