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SAB5701026

Sigma-Aldrich

Anti-GLUT2/SLC2A2 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

monoclonal

form

liquid

species reactivity

human, rat, mouse

concentration

0.63 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

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This Item
SAB5700861SAB1303865SAB5701020
clone

monoclonal

clone

polyclonal

clone

polyclonal

clone

monoclonal

Gene Information

human ... SLC2A2(6514)

Gene Information

human ... SLC2A2(6514)

Gene Information

human ... SLC2A2(6514)

Gene Information

human ... SLC2A1(6513)

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

species reactivity

human, rat, mouse

species reactivity

human, rat, mouse

species reactivity

human

species reactivity

rat, mouse, human

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

flow cytometry: 1:10-1:50, western blot: 1:1000

technique(s)

western blot: 1:500-1:2000

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Immunogen

A synthesized peptide derived from human GLUT2/SLC2A2

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Li Zhu et al.
    The Journal of biological chemistry, 288(44), 32050-32063 (2013-09-21)
    Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellular clearance of amyloid-β (Aβ). Genetic down-regulation of
    Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.
    Wanxia He, Yifeng Lu, Isam Qahwash, Xiang-You Hu, Ansi Chang, Riqiang Yan
    Nature Medicine null
    Beta-secretase activity increases with aging in human, monkey, and mouse brain.
    Fukumoto, H; Rosene, DL; Moss, MB; Raju, S; Hyman, BT; Irizarry, MC
    The American Journal of Pathology null
    7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.
    Devi, L; Ohno, M
    Neuropsychopharmacology null
    Receptor tyrosine kinases positively regulate BACE activity and Amyloid-beta production through enhancing BACE internalization.
    Zou, L; Wang, Z; Shen, L; Bao, GB; Wang, T; Kang, JH; Pei, G
    Cell research null

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