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SAB5701158

Sigma-Aldrich

Anti-CD4 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

monoclonal

form

liquid

species reactivity

human

concentration

0.33 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

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This Item
565788565780565749
form

powder

form

solid

form

lyophilized

form

solid

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

mol wt

~_1.65 kDa

mol wt

-

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble

solubility

DMSO: 100 mg/mL

solubility

DMSO: 1 mg/mL

solubility

DMSO: 5 mg/mL

General description

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Immunogen

A synthesized peptide derived from human CD4

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Jungmi Lee et al.
    Analytica chimica acta, 1022, 89-95 (2018-05-08)
    Amyloid-β (Aβ) is generated by proteolytic processing of amyloid precursor protein (APP) by beta-secretase (BACE-1) and gamma-secretase. Amyloid-β is responsible for the formation of senile plaques in Alzheimer's disease (AD). Consequently, inhibition of β-secretase (BACE-1), a rate-limiting enzyme in the
    Hans Hilpert et al.
    Journal of medicinal chemistry, 56(10), 3980-3995 (2013-04-18)
    An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1
    beta-secretase inhibitor; a promising novel therapeutic drug in Alzheimer?s disease
    Menting KW, et al.
    Frontiers in Aging Neuroscience, 6, 165-165 (2014)
    S Sinha et al.
    Nature, 402(6761), 537-540 (1999-12-11)
    Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide
    Patty C Kandalepas et al.
    Acta neuropathologica, 126(3), 329-352 (2013-07-04)
    β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are increased in AD, which could contribute to pathogenesis, yet the mechanism of BACE1 elevation is unclear. Furthermore, the

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