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SAB5701322

Sigma-Aldrich

Anti- active + pro Caspase-3 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

antibody product type

primary antibodies

form

liquid

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

P42574

shipped in

wet ice

storage temp.

−20°C

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Potassium hydroxide

form

pellets

form

pellets

form

pellets

form

powder

solubility

H2O: 1 M, clear, colorless

solubility

-

solubility

-

solubility

-

assay

≥85% KOH basis

assay

85-100.5%

assay

≥85% KOH basis

assay

≥85%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

pH

~13.5 (25 °C, 5.6 g/L)

pH

~13.5 (25 °C, 5.6 g/L)

pH

~13.5 (25 °C, 5.6 g/L)

pH

~13.5 (25 °C, 5.6 g/L)

impurities

≤0.0005% Phosphorus (P), ≤2.0% K2CO3, ≤0.1% Insoluble matter

impurities

residual solvents, complies, ≤0.0005% heavy metals (as Pb), ≤0.0005% total nitrogen (N), ≤1% K2CO3

impurities

≤2.0% K2CO3

impurities

≤0.002% heavy metals (as Pb), ≤1.0% K2CO3

General description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

Immunogen

A synthesized peptide derived from human active + pro Caspase-3.

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Lot/Batch Number
    4000000133

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