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SBR00077

Sigma-Aldrich

Dapivirine

≥95% (H-NMR), powder

Synonym(s):

TMC 120

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About This Item

Empirical Formula (Hill Notation):
C20H19N5
CAS Number:
244767-67-7
Molecular Weight:
329.40
UNSPSC Code:
51101500

Quality Level

100

assay

≥95% (H-NMR)

form

powder

color

white to off-white

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | inhibits

storage temp.

2-8°C

SMILES string

CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C

InChI

1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)

InChI key

ILAYIAGXTHKHNT-UHFFFAOYSA-N

General description

Dapivirine is an antibiotic from a class of nn-nucleoside reverse transcriptase inhibitor compounds. Dapivirine, a substituted diarylpyrimidine derivative, irreversibly binds to and inhibits HIV reverse transcriptase which prevents the conversion of viral RNA to proviral DNA.

Biochem/physiol Actions

Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor and has activity against wild-type virus strains and strains harboring different NNRTI resistance-inducing mutations.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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